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mitotane will minimize the extent or result of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers lowers plasma concentration of abemaciclib and its metabolites.Mobile proliferation was assessed utilizing a bromodeoxyuridine (BrdU) prolifer